Front | Back |
Neural plate
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- Patch of tissue on the dorsal surface of the embryo
- development begins by chemical signals from ------ |
Totipotent
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Cells that have the ability to become any type of cell in the body if transplanted to the appropriate site
|
Multipotent
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With development, cells are limited to becoming on of the range of mature nervous system cells
|
Neural proliferation
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- the rapid increase in the number of neurons that follow the formation of the neural tube
- chemically guided by ____ and ______ |
Migration
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Cells lack axons and dendrites during this process, two types _____ and _____ and two methods ______ and ______
|
Types of neural tube migration
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- radial: moving OUT, along the radial glial cells
- tangential: moving UP |
Two methods of migration
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- somal: extension develops that leads migration, cell body follows (radial or tangential)
- glial-mediated migration: cell moves along a radial glial network (radial ONLY) |
Neural crest
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- structure dorsal to the neural tube and formed from neural tube cells
- develops into the cells of the peripheral nervous system |
Aggregation
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- after migration, cells align themselves with other cells and form structures
- aided by CAMs |
CAMs
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- aid both migration and aggregation
- recognize and adhere to molecules |
Growth cone
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- amoebalike strudture at the tip of each growing axon or dendrite that guides growth to the appropriate target
|
Chemoaffinity hypothesis
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- postsynaptic targets release a chemical that guides axonal growth
- does not account for circuitous routes often observed |
Fasciculation
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The tendency of developing axons to grow along the paths estabilished by preceding axons
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Topographic gradient hypothesis
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- seeks to explain topographical maps
- axons grow from one topographic surface to another and are guided to specific targets, guided to destinations by 2 intersecting signal gradients |
Neurotrophins
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Promote growth and survival, guide axons, stimulate synaptogenesis
NGF |