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The absorptive state is what time frame
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2 - 4 hr after ingestion of a normal meal.
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Islet tissue of pancreas respond to elevated levels of glucose and aa with secretion of
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Insulin and a drop in release of glucagon
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What makes teh absorptive state into an anabolic period with increase TAG and glycogen replenishing fuel storage
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The elevated Insulin/ Glucagon ration
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Which is elevated in plama during absorptive period (vs postabsorptive state)
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Chylomicrons
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Are acetoacetate, free FA, and lactate levels elevated in the absorptive state?
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No
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What major synthesis is made in liver in absorptive state (besides glucose0
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Fructose 2, 6, BP
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Increased formation of Keton bodies during fasting is a result of
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Free FA bound to albumin are incrase as a result of an incrase activity of Hormone-sensitive lipase in adipose tissue
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Most important source of blood glucose during last hours of a 48-hr fast
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The carbon skeletons of Glycogenic aa used for gluconeogenesis
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Liver glycogen is depleted how soon after a meal?
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12 hours,
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Why can't muscle glycogen give rise to free glucose
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Lacks glucose-6-phosphatase
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Not a source of glucose but part of the glocogenesys pathway
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Acetoacetate that is metabolized to acetyl CoA
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Can arise from anaerobic glycolysis in muscle and RBC, less important than aa as a source of glucose
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Lactic Acid
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Pathway that provides acetyl Coa for Ketogenesis
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B-Oxidation of FA
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Hepatic ketogenesis is stimulated by elevated levels of
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Glucagon
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In what state, fed not fed stae is glucokinaswe synthesis enhanced
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Fed state
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