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Most important source of chemical potential energy in cells
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Electrons
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Why do electrons in ATP have high potential energy?
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Because the four negative charges in its 3 phosphate groups repel each other
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Products of the hydrolysis reaction of ATP
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ADP + Pi (inorganic phosphate) + energy
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Hydrolysis of ATP is a _______ reaction.
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Exergonic
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What can the addition of a phosphate molecule do to a protein?
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The addition of a phosphate molecule to R group of an amino acid residue can turn a hydrophobic portion of a protein into a polar and hydrophilic portion of the molecule. In this way, a phosphate group can introduce a conformational change in the protein.
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Endergonic reactions become exergonic when...
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The substrates or enzymes involved are phosphorylated, thus causing shape change
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What is energetic coupling?
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When a protein is phosphorylated, the exergonic phosphorylation reaction is paired with an endergonic reaction
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What does an oxidation reaction involve?
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A loss/partial loss of electrons (OIL)
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What does a reduction reaction involve?
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A gain or partial gain of electrons (RIG)
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What is NADH?
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-an efficient electron carrier because it readily donates electrons to other molecules--has "reducing power"-It is the reduced form of NAD+.
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What is Cellular respiration?
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--in cells, glucose is oxidized through a long series of carefully controlled redox reactions. The resulting change in free energy is used to synthesize ATP.
--any suite of reactions that produces ATP in an electron transport chain
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What are the 4 steps of cellular respiration?
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1. Glycolysis2. Pyruvate processing3. Citric Acid cycle4. Electron transport chain and chemiosmosis
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Where does glycolysis occur?
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Entirely in the cytosol
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What is substrate level phosphorylation?
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It occurs when an enzyme catalyzes transfer of a phosphate group from an intermediate substrate to ADP (How ATP is produced in glycolysis and the citric acid cycle)
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What is oxidative phosphorylation?
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In an electron transport chain, a proton gradient provides energy for ATP production; the membrane protein ATP synthase uses this energy to phosphorylate ADP-->ATP.
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