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Cards In This Set
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Amount of neurotransmitters
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Many substances are being considered as neurotransmitters and the number will continue to grow
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Major Neurotransmitter Families
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Acetylcholines, monoamines, amino acid transmitters, peptides. Each transmitter is produced by a defined biosynthesis process
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What are potential steps in neuropharmacological compounds
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Each step in synaptic transformation from axonal transport to postynaptic effects
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What is the amino acid precursor for Achetylcholine
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Choline and acetyl coenzyme A
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What drives conversion of choline into Acetylcholine
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Choline acetyltransferase
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What receptors does ACH bind to?
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Muscarinic receptors or nicotinic receptors
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Nicotonic receptors
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ACH are iontropic receptors and are found in the skeletal muscle. Because they are iontropic they are ligand gated which means they will act faster and not last as long. EPSP's
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Muscarinic receptors
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ACH are metabotropic receptors and are found in the PNS and CNS. Metabotropic takes longer and last longer which is better for learning and memory processes. IPSP.
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Where is ACH heavily located in the brain?
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Nucleus Basilis and sends projections to cortex and limbic regions
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Where and what is ACH broken down by?
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In the synapse by Acetylcholinesterase
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Which neurotransmitters have similar biochemical pathways?
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NE and DA
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The amino acid tyrosine is converted to...
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L-Dopa by tyrosine hydroxylase
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For dopamine...what converts L-Dopa to dopamine?
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Dopa-decaryboxylase
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For NE what converts L-Dopa into NE?
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Dopamine-beta-hydroxylase
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What are DA and NE deactivated by?
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Reuptake and MAO (monoamine oxidase)
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