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Grifith
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Conclusion..r bacteria gets transformed into s bacteria by some chemical component that is heritable ..called this transformation
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Avery, mccarty, n macleod
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Wanted to know what transforming factor was: dna rna and protein
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Conclusion of aver, mccarty n macleod
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Dna is "transforming factor" in these bacteria ...suggests that dna is heritable material in bacteria
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Hershey and chase experiments
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Studied bacteriaphage (phage)
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Bacteriophage(phage)
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Viruses that infect bacteria..contain a few of own genes-take over host cell and convert it into factory for making more viruses
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Conclusion of hershey/chase experiment
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No protein got into the bacterial cell..-phage dna got into bacterial cell=dna was passed from the phage to the bacteria-phage dna but not proteins entered the bacterial cells-dna functions as genetic material for T2 (phage)
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What functions as genetic material for T2 (phage)
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Dna
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Erwin chagoff's contributions
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Knew dna was a polymer w/ nitrogenous bases: A, T, G, C-studied amt of each base in diff species-found it was diff in each species but A=t & G=C but A+T doesnt = G+C
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Chargoff's rule
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Allowed watson & crick to figure out that bases paired in double helix
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If 28% of the bases in a particular species are A what percentage are T? G? C?
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A=28, T=28 A+T=56- G+C=44-G=22, C=22
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