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Phases of Interphase
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G1 (post mitotic), S (synthesis), G2 (pre-mitotic), G0 (amniotic cells)
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G1 (post mitotic) phase
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Interphase. Cell regains normal size, very active. Varies in length of time.
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S (synthesis) phase
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Interphase. Cell manufactures second set of chromosomes.
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G2 (pre mitotic) phase
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Interphase. Cell produces additional organelles and cytoplasm needed to divide.
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G0
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Interphase – amniotic cells. Don’t reproduce outside of womb (ie, neurons, myocardial cells).
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Phases of mitosis (aka “M phase”)
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Prophase, metaphase, anaphase, telophase, cytokinesis
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Prophase
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Nucleoli and nuclear membranes disappear. DNA condenses into chromosomes. Centrioles separate and move to opposite ends of cell, anchored by astral fibers. Spindle fibers stretch from centromere to centriole on each DNA strand.
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Metaphase
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Chromosome pairs line up in middle cell on metaphase plate.
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Anaphase
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Spindle fibers shorten and pull chromosomes to opposite poles of cell.
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Telophase
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Prophase events are reversed; nuclear membrane & nucleoli reforms, chromosomes become chromatin
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Cytokinesis
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Cell separates along cleavage furrow
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Positive Feedback
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Begins with a stimulus that triggers a body response. The response triggers a stronger stimulus, which causes a stronger response. Two examples: parturition & blood clotting. Seen in disease processes.
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Negative Feedback
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A stimulus (internal or external) is perceived that triggers a response. The response corrects the stimulus.
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