Front | Back |
Any substance that can cause
developmental abnormalities in the embryo or fetus
|
Teratogen
|
Examples of teratogens - 5
|
Pharmaceuticals, alcohol/smoking/drugs,
infection, radiation, maternal disease
|
Medications with known teratogencity - 5
|
Thalidomide, accutane, tetracycline,
coumadin, antidepressants
|
Hazards of smoking during pregnancy
|
Placenta previa, placental abruption,
low birthweight/prematurity
|
What happens with oxygen during smoking
|
Carbon monoxide binds with hemoglobin
instead of oxygen
|
Marijuana causes
|
Tremors and startle reflexes in
newborns
|
Cocaine causes
|
Vasoconstriction to the uterus and
cocaine addiction in babies
|
Illnesses causing damage (STORCH) - 7
|
syphilis, toxoplasmosis, rubella,
cytomegalovirus, herpes, measles, mumps
|
Radiation as teratogen
|
High ionizing radiation (ie gamma rays)
can cause death for fetus and newborn. Lower doses cause congenital
abnormalities and growth retardation and cancer.
|
Does UV radiation affect fetus?
|
No
|
Etiology of harm due to teratogen
exposure depends on:
|
Timing of exposure – very early or
very late is less harmful
|
First two weeks:
|
Embryo has not implanted yet and result
of teratogen exposure may be minimal
|
Weeks 2-5:
|
CNS, eye, and limb buds may be affected
|
Weeks 4-7:
|
CNS, heart, eye, ear, limbs,
mouth/teeth may be affected
|
Weeks 6-10:
|
CNS, heart, limbs, senses, digestive
system, genitalia
|