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Signal transduction pathway
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The recieved signal is converted to a specific cellular response in a series of steps
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Local regulators
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Messenger molecules that travel only short distances and influence cells in the vicinity
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Hormones
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Used for long distance signaling
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Ligand
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A molecule that specifically binds to another molecule
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G protein coupled receptors
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comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses.
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Receptor tyrosine kinase
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the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Ion channel receptors
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cell membrane bound receptors. They act through synaptic signaling on electrically excitable cells. The ion channels opening and closing is controlled by neurotransmitters.
Ion-channel-linked receptors are also called ligand-gated channels. These membrane-spanning proteins undergo a conformational change when a ligand binds to them so that a "tunnel" is opened through the membrane to allow the passage of a specific molecule. These ligands can be neurotransmitters or peptide hormones, and the molecules that pass through are often ions, such as sodium (Na+) or potassium(K+), which can alter the charge across the membrane. The ion channels, or pores, are opened only for a short time, after which the ligand dissociates from the receptor and the receptor is available once again for a new ligand to bind.
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Protein kinase
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An enzyme that transfers phosphate groups from ATP to a protein
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Protein phosphatase
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Enzymes that can rapidly remove phosphate groups from proteins
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Second messengers
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These messengers differ in the mechanism by which they are produced and removed, as well as their downstream targets and effects
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Cyclic AMP
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Binding of epinephrine to the plasma membrane of a liver cell elevates the cytosolic concentration of a compound
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Adenylyl cyclase
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Converts ATP to CAMP in response to an extracellular signal
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IP3
DAG |
2nd messenger produced by cleavage of a certain kind of phospholipid
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Scaffolding proteins
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Large relay proteins to which several other relay proteins are simotaneously attached
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Apoptosis
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Cells that are infected or damaged undergo programmed cell death
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