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Cards In This Set
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MOPP
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M = MechlorethamineO = Onvocin (vincristine)P = ProcarbazineP = PrednisoneSE: leukemia and infertilityTx for Stage 3 and 4 Hodkin's Lymphoma
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ABVD
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A = Adriamycin (cardiotoxicity)B = Bleomycin (lung toxicity = pulmonary fibrosis)V = Vinblastine (peripheral neuropathy; stock and glove effect)D = DacarbazineSE: lung and cardiac toxicities, but much better than MOPP leukemia and infertility SETx: Stage 3 and 4 Hodkin's Lymphoma
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PEB
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P = Platinum (cisplatin)E = Etoposide (mitotic spindle inhibitor)B = Bleomycin (Anti-cancer antibiotic)Tx: metastatic testicular cancer
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BCG
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Stimulates cell-mediated immunityTx: melanoma and bladder cancerSE: can cause miliary TB if there is break in urethra
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Interferon Alpha
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Stimulates cytotoxicityTx: Melanoma and Kaposi's SarcomaSE: depression! (INF interferes with your cognitive function)
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Interleukin - 2
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Stimulates NK number and activityTx: treats melanoma and renal cell cancerSE: flu-like illness, toxicity to BM, liver, kidney
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ATRA
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All-trans retinoic AcidMOA: causes differentiation of promyelocytes to myelocytes Tx: AML-M3 (Auer Rods, DIC); t(15:17)Young Hispanic Females
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Rituximab
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Works on CD20 B cellsTx: B cell lymphomasDoesn't work on Hodgkin's lymphoma because it is absent of CD20 markerSE: allergic reaction
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Trastuzumab
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Aka HerceptinHER2/neu receptor (epidermal growth factor receptor for breast)May cause cardiotoxicity
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Bevacizumab
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Monoclonal Ab to VEGF (vasoactive endothelial growth factor receptor)Prevents new blood vessel formation - angiogenesisTx: metastatic colon cancer and macular degenerationExpensive!
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Cetuximab
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EGFR - epidermal growth factor receptorMetastatic colon cancerHead and Neck Squamous cell cancer
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Imatinib (Gleevac)
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Bcr-abl Philadelphia chromosome; t(9:22)Inhibits the bcr-abl tyrosine kinase (in CML) and c-kit tyrosine kinase (in GIST)Blocks the proliferation and induces apoptosis; binds the CML enzyme and prevents ATP from binding to it to allow downstream signalingSE: edema, toxicity to BM, Liver
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Erlotinib
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Non-small cell lung cancer (adenocarcinoma)SE: acneform rash
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Thalidomide
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Inhibits angiogenesisTx: Multiple Myeloma
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Velcade
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Inhibits proteosomeTx. Multiple Myeloma
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