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Erythropoetin
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-Hormone made by kidneys-Tells body to increase RBC production
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Destruction of RBC's
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-Spleen and liver phagocytize-Aged, abnormal, damaged RBC's-Macrophages (in spleen and liver)
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Function of RBC/Erythrocytes
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Transports O2 and CO2
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DeoxyHB ---> OxyHB
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HB + O2 --(lungs)--> HbO2 -- (tissues)--> HB + O2
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Protein Chain
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-Each chain: Globin-Globin bound to heme group
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Forming Oxyhemoglobin (OxyHb)
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- 1 Hb molecule binds to 4 O2 molecules
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Forming carbaminoHb
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-Hb can bind with CO2-Globin portion of Hb binds with CO2
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Neutrophils
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Most abundant of RBC's
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All WBC can do what 2 things?
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1. Diapedesis2. Chemotaxis
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Diapedesis
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Ability to leave blood vessel and enter tissue
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Chemotaxis
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Damaged cells release chemicals to attract WBC's (leukocytes)
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Basophils Release 2 things
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1. Histamine2. Heparin
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Histamine
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-Stressed Cells-Promotes inflammation
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Heparin
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-Inhibits blood clotting-Anticoagulant
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What do monocytes become once they leave the bloodstream?
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Macrophages
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