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Cards In This Set
| Front | Back |
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Most common life-threatening birth defects
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Heart defects
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Make up ___% of all congenital defects in live births (~1:200).
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20%
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4 main causes
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The heart is the 1st functioning organ; it starts to pump blood around day ____ of
development.
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24
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How does embryonic development of the heart begin?
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It begins by differentiation and formation of cell clusters called angioblasts within the precardiac splanchnic mesoderm
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What day does hetatopoiesis occur and where?
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Day 17 in mesoderm adjacent to the endoderm of yolk sac wall
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Hemangioblasts differentiate into:
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Hematopoietic stem cells and endothelial precursor cells.
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Sites of hematopoiesis in chronological order are
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1. blood islands of the yolk sac2. liver3. AGM4. spleen5.bone marrow
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End of the third week you have (end of 21 days)
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Vascularized yolk sac wall, connecting stalk and chorionic villi
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Vasculogenesis
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Making blood vessels directly from mesenchyme
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Explain difference between extraembryonic vasculogenesis and intraembyronic vasculogenesis
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Extra: vasculogenesis is coupled with hematopoiesis
intra: with exception to AGM region, bv formation within embryo is NOT coupled with hematopoesis |
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What day and where does intraembryonic vasculogeneisis occur?
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By day 18, see vessel formation in the intraembryonic splanchnopleuric mesoderm
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A subset of cells in the intraembryonic splanchnic mesoderm differentiates into ________. These then differentiate into
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Endothelial precursor cells (angioblasts).These then differ into endothelial cells that organize into small vesicle-like structures and coalesce to form long tubes
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What are angiomas? what are they caused by, stimulated by.
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Caused by abnormal blood vessel and lymphatic growth, likely stimulated by abnormal levels of angiogenic factors.
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Excessive growth of small capillary network
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Capillary hemanigioma
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