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Cards In This Set
| Front | Back |
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Adrenergic bronchodilator
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Agent that stimulates sympathetic nervous fibers
allows smooth muscle relaxation |
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Adrenergic bronchodilators are also known as
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Sympathomimetic bronchodilators or B2 agonists
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Adrenergic bronchodilator uses
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Relaxation of smooth airway muscle in the presence of reversible obstruciton
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Clinical indications for Bronchodilators
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Asthma, bronchitis, emphysema, bronchiectasis, COPD
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Indication for sabas (rescue)
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Relief of acute reversable airflow obstruction in asthma or other obstructive airway diesases
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Indication for LABAs (maintanence)
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Control of bronchospasms and nocturnal symptoms of asthma or other obstructive diseases
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LABAS are usually combined with what type of medication?
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Antiinflammatory drugs
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Indicaiton for racemic epinephrine
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Reduce airway swelling
post extubation stridor, epiglottitis, croup, bronchiolits control bleeding during endoscopy |
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USABS
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Duration < 3 hours
epinephrine and racemic epinephrine |
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SABA description
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Onset: minutes
peak 30-60 minutes duration 4-6 hours albuterol, levalbuterol, pirbuterol, metaproteronol |
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LABA description
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Onset 15-30 minutes
peak 3-6 hours duration 12 hours salmeterol, formoterol, arformeterol |
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Catecholamines
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Chemical structure consisting of an aromatic catechol nucleus and a dialiphatic amine side chain
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Cateolamines are what type of amines?
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Sympathomimetic: mimic the effects of epinephrine
cause tachycardia, increased BP, smooth muscle relaxation, skeletal muscle tremor and CNS stimulation |
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Structure of catecholamines
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Benzene ring, two hydroxyl groups, with an amine side chain
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Adrenergic bronchodilators as stereoisomers
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Non superimposable molecules that mirror each other
R isomer ( right) S isomer (left) |
