Front
|
Back
|
|
- Afferent neurons - Sensory neurons that carry nerve impulses from sensory stimuli towards the central nervous system (CNS) & brain
- Efferent neurons - Motor neurons that carry neural impulses away from the CNS & towards muscles to cause movement
- (1) Sensory receptor --> (2) Sensory (afferent) neuron --> (3) Interneuron --> (4) Motor (efferent) neuron --> (5) Effector organ
|
|
- Specialized neurons or nerve endings that respond to changes in the environment by converting energy from a specific stimulus into an action potential (AP) (a process known as transduction)
- Sensory nerve endings that respond to stimuli by developing APs
|
|
Sensory Receptor Cells --> Type of Energy Reception --> Sense Organ - Vision --> Photoreception: Detection of light, perceived as sight --> Eyes
- Hearing --> Mechanoreception: Detection of vibration, perceived as hearing --> Ears
- Touch --> Mechanoreception: Detection of pressure, perceived as touch --> Skin
- Smell --> Chemoreception: Detection of chemical stimuli, perceived as smell --> Nose
- Taste --> Chemoreception: Detection of chemical stimuli, perceived as taste --> Tongue
|
|
- Range from single cells to complex sense organs
- Types of receptors
- Chemoreceptors - Chemicals (smell & taste)
- Mechanoreceptors - Pressure & movement (touch, hearing, balance, blood pressure)
- Photoreceptors - Light (vision)
- Electroreceptors - Electrical fields
- Magnetoreceptors - Magnetic fields
- Thermoreceptors - Temperature
|
|
Sense --> Stimulus --> Sense Organ --> Receptor --> Sensation - Sight --> Light waves --> Eye --> Rods & cones of retina --> Colors, patterns, textures, motion, depth in space
- Hearing --> Sound waves --> Ear --> Hair cells located in inner ear --> Noises, tones
- Skin sensations --> External contact --> Skin --> Nerve endings in skin --> Touch, pain, warmth, cold
- Smell --> Volatile substances --> Nose --> Hair cells of olfactory membrane --> Odors (musky, flowery, burnt, minty)
- Taste --> Soluble substances --> Tongue --> Taste buds of tongue --> Flavors (sweet, sour, salty, bitter)
- Vestibular sense --> Mechanical & gravitational forces --> Inner ear --> Hair cells of semicircular canals & vestibule --> Spatial movement, gravitational pull
- Kinesthesis --> Body movement --> Muscles, tendons --> Nerve fibers in muscles, tendons, & joints --> Movement & position of body parts
|
Classification of Sensory Receptors
|
- Based on stimulus location:
- Telereceptors - Detect distant stimuli (i.e., vision & hearing)
- Exteroceptors - Detect stimuli on the outside of the body (i.e., pressure & temperature)
- Interoceptors - Detect stimuli inside the body (i.e., blood pressure & blood oxygen)
|
|
- All receptors transduce incoming stimuli into changes in membrane potential
- Receptor protein detects stimulus
- Opening or closing of ion channel
- Change in membrane potential
- Signal sent to integrating center (central nervous system)
|
Sensory Signal Transduction Pathways
|
- Ionotropic sensory receptors
- Mechanoreceptor: Pressure opens an ion channel
- Thermoreceptor: Temperature influences a membrane protein that is a cation channel or is closely associated w/ the channel
- Electroreceptor: An electric charge opens an ion channel
- Metabotropic sensory receptors
- Chemoreceptor: A molecule binds to a receptor, initiating a signal that controls the ion channel via second messenger cascade
- Photoreceptor: Light alters a receptor protein, initiating a signaling cascade that controls an ion channel
|
|
ALL --> INTRACELLULAR EFFECTS - Ligand-gated ion channels (LIC, LGIC) (ex. cholinergic nicotinic receptors) --> Changes in membrane potential or ionic concentration within cell
- G protein-coupled receptors (GPCR) (ex. α & β adrenoceptors) --> Protein phosphorylation
- Enzyme-linked receptors (ex. insulin receptors) --> Protein & receptor phosphorylation
- Intracellular receptors (ex. steroid receptors) --> Protein phosphorylation & altered gene expression
|
|
- All stimuli are ultimately converted into action potentials (APs) in afferent (sensory) neurons
- Sensory receptors & sensory neurons must encode 4 types of information
- Stimulus modality - The category of sensory input that a sensory system detects
- Stimulus location - The ability to precisely localize a stimulus
- Receptive field size - The smaller the receptive field, the better the acuity
- Receptor density - The more receptors/receptive field, the better the acuity
- Stimulus intensity
- Threshold: The minimum intensity of a stimulus that is required to produce a response from a sensory system
- Saturation: The maximum intensity of a stimulus that produces a response from a sensory system
- Dynamic Range: The range of intensities that will produce a response from a receptor or sensory system (i.e., the difference between threshold & saturation)
- Stimulus duration - The length of a time a stimulus must be applied for the resulting nerve impulse to produce excitation in the receptor. More intense stimuli require shorter excitation times to effect a cellular response. Any stimulus that acts too briefly to overcome the threshold intensity of the receptor will not elicit a response
|
|
- Most cells can sense chemical stimuli
- Animals have many types of chemoreceptors
- Olfaction (smell) - Detection of chemicals in the air
- Pheromones - A chemical substance produced & released into the environment by an animal, especially a mammal or an insect, affecting the behavior or physiology of others of its species
- Gustation (taste) - Detection of chemicals emitted from food
|
The Vertebrate Olfactory System
|
- Can distinguish between thousands of odorants
- Located in the roof of the nasal cavity
- Mucus layer to moisten olfactory epithelium
- Odorant binding proteins
- Allow lipophilic odorants to dissolve in mucus
- Odorant receptor is linked to G-protein
- Odorant binding causes formation of cAMP
- Opening of ion channels
- Depolarization
|
|
- 5 classes of tastants
- Salty
- Sweet
- Bitter
- Sour
- Umami (savory or meaty) - Japanese belief that there is a 5th taste sense that triggers our need for protein (shiitake mushrooms & asparagus)
- Sweet, umami, & salty indicate carbohydrates, proteins, & ions
- Bitter & sour indicate potentially toxic substances
|
Taste Buds in Vertebrates
|
- Taste receptors are epithelial cells that release neurotransmitter
- Vertebrate taste receptors are not neurons
- Taste receptor cells clustered in groups
- On tongue, soft palate, larynx, & esophagus
- A species' taste sensitivity depends on how many taste buds it has
- Animals use taste to determine if food is safe to eat. Herbivores have so many taste buds b/c they need to be able to tell if a specific plant contains dangerous toxins
|
|
- Transform mechanical stimuli (touch or sound) into electrical signals
- All organisms (& most cells) sense & respond to mechanical stimuli
|