50 Mitochondrial Oxidative Phosphorylation

54 cards   |   Total Attempts: 188
  

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OxPhos is the major process for formation of what?
OxPhos is major process for formation of ATP in most cells
OxPhos is divided into 2 processes. what are they?
(1) exergonic electron transport from NADH + H and FADH2 to O2 via intermediate carriers (2) endergonic syn of ATP
______ is the terminal electron acceptor to yield _____
O2 is the terminal electron acceptor to yield H2O
What are the 2 waste products of cellular respiration?
CO2 and H2O
Where are electrons passed thru redox carriers?
Inner mitochondrial membrane
As electrons pass thru redox carriers in the inner mitochondrial membrane, what happens to protons?
They move outward, creating a gradient.  re-entry of protons thru pore in ATP synthase drives ATP syn
What are the 2 components of OxPhos regulation?
(1) energy need (2) availability of ADP & Pi
Describe permeabilities of the inner and outer mitochondrial membranes
Outer membrane: permeable to anions & small molecules inner membrane: impermeable to almost everything
What 2 things are embedded in teh inner mitochondrial membrane?
(1) protein complexes/ electron carriers (2) ATP synthase (projects inot matrix to generate ATP)
Is the ETC energetically favorable or unfavorable?  how many ATP molecules are syn'd from NADH?
Energetically FAVORABLE 3 ATP molecules are syn'd
Name the 6 enzymes & electron carriers of ETC
(1) NADH DHD
(2) Coenzyme Q (3) Complex II (4) Cytochrome b-c1 (5) cytochrome c (6) cytochrome oxidase (complex IV)
Describe NADH DHD (related complex, components, what do components accept?)
(1)NADH DHD is a huge complex (COMPLEX I) (2) has FMN + Fe-S centers (3) FMN accepts e's from NADH and sends them to Fe-S centers (4)NADH oxidized to NAD
What happens to teh electrons that were passes to Fe-S centers by FMN in complex I?
They are given to coenzyme Q
What is significant about CoQ?
It is NOT protein bound, so it is freely moveable (2) diffuses thru lipids of inner mitoch membrane (3) red/ox of CoQ associated with transmembrane movement, this is part of proton pumping
Complex II conencts what to what?
Complex II (succindate DHD) connects respiratory chain of inner mitoch membrane with TCA cycle enzymes in mitochondrial matrix